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LumiChip outline

With collaboration with professor Shimshon Belkin's group in Israel, we have developed a platform for bioluminescence detection of pollutants in water by the genetically engineered bacteria.
There are several key points to our development.
1. detection based on simple high sensitive linear CCD. 
Instead of using very expensive scientific CCD that usually needs to be thermoelectrically cooled for sensitivity and lower noise, we are using a highly sensitive linear CCD without cooling. The CCD is commonly found as the sensor in POS scanner.
2. Integrated cell culture platform on chip and direct interface for detection.
Because the bioluminescence from the bacteria is really weak, In this study, we miniaturized the entire setup to directly interface the chip onto the CCD surface for maximum light collection efficiency. 
Also we have found that temperature is very important for shortening the response time for bioluminescence generation after stimulation. With a integrated heater on the chip and the essence of the small size of the chip, we can have low power consumption heating of the chip and good temperature uniformity. The chip is essentially a bacteria culturing platform.
Heating to optimal temperature is essential to shorten the response time and maximize the bioluminescence.

The work has just been published on lab on chip.

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